Diclofenac sodium, a biopharmaceutics classification system (BCS) Class II drug, exhibits poor aqueous solubility, resulting in dissolution-limited oral absorption. This study aimed to enhance its solubility and dissolution by preparing solid dispersions with polyvinylpyrrolidone K30 (PVP K30) using the solvent evaporation method. Formulations containing drug-to-polymer ratios of 1:2, 1:3 and 1:4 were evaluated for drug content, saturation solubility and in-vitro dissolution. All formulations showed acceptable drug content (93.7–97.4%) and improved solubility compared with the pure drug. The 1:4 formulations exhibited the highest solubility (10.54 µg/ml) and released 96.3% of the drug within 60 minutes, compared with 54.8% for pure diclofenac sodium. These findings demonstrate that PVP K30-based solid dispersions effectively improve the solubility and dissolution of diclofenac sodium.
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